Product Description

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Cynomolgus (Macacafascicularis)monkey (cyno) C1q is purified from pooled normal cynoserum. C1q ispart of the C1 complex,which is the first complement component in theclassical pathway ofcomplement. The C1 complex is anon-covalentassembly of three different proteins (C1q, C1r, and C1s) boundtogetherin a calcium-dependent complex.C1q has six extended arms withdomains at the end of each arm that bindto the Fc domains ofimmunoglobulins such as IgG or IgM. When antibodies bind to antigens,formingimmune complexes, they cluster allowing two or more of the sixC1q arms to bindto the Fc domains of antibodies. Thebinding ofmultiple arms of C1q to immune complexes causes the two C1r proteinsinthe complex (protease zymogens) to auto-activate. The activated C1r proteases cleave and activate the two C1s protease zymogens in the complex. The activated C1s cleavescomplement component C4 releasingC4a and initiating covalent attachment of C4bto the activatingsurface. Activated C1salso cleaves C2 and the larger fragment of C2binds to the surface-attached C4bforming C4b,C2a, the C3/C5 convertaseof the classical pathway.

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